KMID : 0356420040220010036
|
|
Journal of Korean Andrology 2004 Volume.22 No. 1 p.36 ~ p.40
|
|
Combination Therapy of Intraurethral Condyloma Acuminatum with Holmium:YAG Laser and 5-Fluorouracil Instillation
|
|
Kim Il-Whan
Cho In-Rae Lee Keon-Cheol Jeon Joon-Seong
|
|
Abstract
|
|
|
Purpose: Condyloma acuminatum is a common sexually transmitted disease of the external genitalia and anus. Approximately 5% of patients demonstrate urethral involvement. Electrical fulguration or excision using a pediatric resectoscope has been used in the management of such lesions. Holmium(Ho):YAG laser, 5-FU (fluorouracil), or interferon may be helpful in eradicating them. We reviewed the results of intraurethral condyloma acuminatum treatment with Ho:YAG laser and 5-FU solution.
Materials and Methods: From January 2001 to July 2002, seven patients with intraurethral condylomata acuminata were enrolled in the study. The mean age of the subjects was 19.5 (range 25¡43) years. Under local anesthesia with 10% lidocaine spray and jelly, all of the intraurethral lesions were removed with the Ho:YAG laser followed by coverage with 10mL of 5% 5-FU solution. Intraurethral injection of 5-FU was performed weekly up to six times. Urethroscopy for detection of recurrence was done 3 months after initial laser therapy.
Results: Most patients had multiple intraurethral lesions. Six patients (86%) responded to initial therapy without local recurrence witha mean follow-up of 15.8 (range 9.1-23.2) months. One patient had a recurrence at 2 months.
Conclusions: We believe that the Ho:YAG laser plus 5% 5-FU solution is a useful option for the treatment of intraurethral condyloma acuminatum.
|
|
KEYWORD
|
|
Condyloma acuminatum, 5-Fluorouracil, Holmium:YAG laser, Urethral lesions
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|